Inflammation-induced anorexia and fever are elicited by distinct prostaglandin dependent mechanisms, whereas conditioned taste aversion is prostaglandin independent
نویسندگان
چکیده
منابع مشابه
Inflammation-induced anorexia and fever are elicited by distinct prostaglandin dependent mechanisms, whereas conditioned taste aversion is prostaglandin independent
Systemic inflammation evokes an array of brain-mediated responses including fever, anorexia and taste aversion. Both fever and anorexia are prostaglandin dependent but it has been unclear if the cell-type that synthesizes the critical prostaglandins is the same. Here we show that pharmacological inhibition or genetic deletion of cyclooxygenase (COX)-2, but not of COX-1, attenuates inflammation-...
متن کاملAmygdala-dependent mechanisms underlying memory retrieval of conditioned taste aversion.
Conditioned taste aversion (CTA) is an associative learning phenomenon in which ingestion of a novel tasting food or fluid (conditioned stimulus, CS) is paired with visceral malaise (unconditioned stimulus, US) (Yamamoto et al., 1994). Conditioned animals avoid ingesting the tastant previously associated with the condition of sickness. Since CTA is established by a single pairing of the CS and ...
متن کاملEndogenous opioids: role in prostaglandin-dependent and -independent fever.
This study evaluated the participation of mu-opioid-receptor activation in body temperature (T(b)) during normal and febrile conditions (including activation of heat conservation mechanisms) and in different pathways of LPS-induced fever. The intracerebroventricular treatment of male Wistar rats with the selective opioid mu-receptor-antagonist cyclic d-Phe-Cys-Try-d-Trp-Arg-Thr-Pen-Thr-NH(2) (C...
متن کاملThe role of interleukin-6 in lipopolysaccharide-induced fever by mechanisms independent of prostaglandin E2.
Fever has been shown to be elicited by prostaglandin E(2) (PGE(2)) binding to its receptors on thermoregulatory neurons in the anterior hypothalamus. The signals that trigger PGE(2) production are thought to include proinflammatory cytokines, such as IL-6. However, although the presence of IL-6 is critical for fever, IL-6 by itself is not or only weakly pyrogenic. Here we examined the relations...
متن کاملProstaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation-induced aversion in mice.
Systemic inflammation causes malaise and general feelings of discomfort. This fundamental aspect of the sickness response reduces the quality of life for people suffering from chronic inflammatory diseases and is a nuisance during mild infections like common colds or the flu. To investigate how inflammation is perceived as unpleasant and causes negative affect, we used a behavioral test in whic...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Brain, Behavior, and Immunity
سال: 2017
ISSN: 0889-1591
DOI: 10.1016/j.bbi.2016.12.007